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Intracytoplasmic morphologically selected sperm injection (IMSI) is a high magnification light microscopy imaging method used increasingly in the field of in vitro fertilisation (IVF) to select sperm for ICSI (intracytoplasmic sperm injection). This technique has been shown to increase pregnancy rates and reduce abortion rates compared to routine ICSI-IVF. The IMSI method is based on motile sperm organellar morphology examination (MSOME) at magnifications in excess of 6000x to select sperm with morphologically normal nuclei. High magnification in the IMSI method reveals critical details in sperm morphology, especially that of the nucleus, allowing selection of highest quality sperm for ICSI. Microinjection of sperm with a morphologically normal nucleus significantly improves IVF success.
This new technique launched for the first time in India at Manipal Fertility, helps our embryologist to view sperm magnified 7200x as compared to conventional one where the magnification is just 200x. The success rates of IMSI at Manipal Fertility are higher compared to the conventional techniques, but could vary among different age groups.



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